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Open Access Highly Accessed Review

Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions

Jeffrey S Han

Author Affiliations

Department of Embryology, Carnegie Institution of Washington, Baltimore, MD, USA

Mobile DNA 2010, 1:15  doi:10.1186/1759-8753-1-15

Published: 12 May 2010

Abstract

Non-long terminal repeat (non-LTR) retrotransposons are present in most eukaryotic genomes. In some species, such as humans, these elements are the most abundant genome sequence and continue to replicate to this day, creating a source of endogenous mutations and potential genotoxic stress. This review will provide a general outline of the replicative cycle of non-LTR retrotransposons. Recent findings regarding the host regulation of non-LTR retrotransposons will be summarized. Finally, future directions of interest will be discussed.